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Cosmesis, late sequelae and local control after breast-conserving therapy: influence of type of tumour bed boost and adjuvant chemotherapy

In Clinical Oncology
By: Budrukkar AN.
Contributor(s): Deshpande D | Shrivastava SK | Sarin R | dinshaw.tmc@vsnl.com <dinshaw.tmc@vsnl.com> | Dinshaw KA.
Material type: materialTypeLabelArticleSeries: Vol 19 Issues 8.Publisher: 2007Description: 596-603.Subject(s): India | Radiation sequelae | cosmesis | Chemotherapy | Breast conservation | Brachytherapy | Boost | DDC classification: In: Clinical OncologySummary: Aims To study the influence of various factors affecting cosmetic outcome and late sequelae in a large cohort of women treated with breast-conserving therapy. Materials and methods Between 1980 and 2000, 1022 pathological stage I/II breast cancer patients underwent breast-conserving therapy. On the basis of the type of tumour bed boost they received after whole breast radiotherapy, these women were assigned to three groups: (A) low dose rate (LDR) brachytherapy of 1520 Gy (n = 383); (B) high dose rate (HDR) brachytherapy of 10 Gy (optimised) in a single fraction (n = 153); (C) electron beam 15 Gy/six fractions (n = 460). Systemic adjuvant therapy was given to 757 women, of whom 570 received adjuvant chemotherapy. Results Cosmesis at the last follow-up was good or excellent in 77% of women. Post-radiation worsening of cosmesis was observed in 11.5% of women and was similar in the three boost groups. Moderate to severe late breast sequelae were observed in 22% of women in group B, which was signifi
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Articles Articles Tata Memorial Hospital
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Aims
To study the influence of various factors affecting cosmetic outcome and late sequelae in a large cohort of women treated with breast-conserving therapy.
Materials and methods
Between 1980 and 2000, 1022 pathological stage I/II breast cancer patients underwent breast-conserving therapy. On the basis of the type of tumour bed boost they received after whole breast radiotherapy, these women were assigned to three groups: (A) low dose rate (LDR) brachytherapy of 1520 Gy (n = 383); (B) high dose rate (HDR) brachytherapy of 10 Gy (optimised) in a single fraction (n = 153); (C) electron beam 15 Gy/six fractions (n = 460). Systemic adjuvant therapy was given to 757 women, of whom 570 received adjuvant chemotherapy.
Results
Cosmesis at the last follow-up was good or excellent in 77% of women. Post-radiation worsening of cosmesis was observed in 11.5% of women and was similar in the three boost groups. Moderate to severe late breast sequelae were observed in 22% of women in group B, which was signifi

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